Written by: Patrick Palmero



Time to read 6 min

The Endocannabinoid Clock: Gauging How Long Does CBD Stay in Your System

As an in-house CBD expert at NanoCraft, my journey into understanding and sharing the nuances of CBD has been both enlightening and fascinating. Cannabidiol (CBD), a remarkable compound found in cannabis plants, has garnered widespread attention and curiosity. My experience in the field has allowed me to delve deeply into the intricacies of CBD, including a question many of our customers frequently ask: "How long does CBD stay in your system?" Drawing from scientific research and practical insights, I aim to shed light on this question, guiding those who turn to CBD for its numerous health and wellness benefits.

Introduction to CBD

Cannabidiol, more commonly known as CBD, has rapidly become a cornerstone in the wellness and health sectors. Extracted from the cannabis plant, it is one of over a hundred cannabinoids identified in hemp plants. CBD's rising fame can largely be attributed to its non-psychoactive nature, distinguishing it significantly from THC (tetrahydrocannabinol), the compound responsible for the 'high' in marijuana. This unique characteristic of CBD allows users to experience the therapeutic benefits of cannabis without the psychoactive effects, making it an appealing option for those seeking natural remedies for various health conditions, without the mind-altering effects often associated with marijuana use.

The Various Benefits of CBD

The widespread acclaim for CBD stems from its versatile health benefits, which have been the subject of numerous studies and anecdotal evidence. Its popularity is primarily due to its potential effectiveness in:

  • Alleviating Mental Health Disorders: CBD has been reported to have calming effects on the nervous system, which can be beneficial in managing symptoms of anxiety and depression. By potentially regulating mood and reducing stress levels, CBD offers a natural approach to mental wellness.
  • Pain and Inflammation Management: CBD's interaction with the endocannabinoid system is believed to reduce inflammation and mitigate pain. This has made it a popular alternative for individuals dealing with chronic pain conditions, such as arthritis and fibromyalgia. There are many specific products to treat CBD for Pain.
  • Improving Sleep Quality: By promoting relaxation and reducing anxiety, CBD can indirectly aid in improving sleep patterns and quality. This is particularly beneficial for those struggling with sleep disorders like insomnia.


These benefits of CBD are attributed to its interaction with the body's endocannabinoid system (ECS). The ECS plays a crucial role in regulating a wide range of bodily functions, including pain sensation, mood, appetite, and immune system responses, positioning CBD as a multi-faceted remedy in the natural wellness space. The question is how long can you expect to see the benefits from CBD? This is determined by finding out, How long does CBD stay in your system. As there are multiple factors that effect this.

Scientific Insights: How Long Does CBD Stay in Your System?

One common question among CBD users is, "How long does CBD stay in your system?" The answer varies based on several factors, including the method of consumption, the dosage, the frequency of use, and the user's metabolism. Generally, CBD can stay in the system for anywhere from a few days to a couple of weeks.

Factors Influencing CBD Retention

  • Method of Consumption: CBD can be ingested in various forms, including oils, tinctures, gummies, and topical applications. The method of consumption affects how quickly CBD is metabolized and how long it remains in the body.
  • Dosage and Frequency: Higher doses and more frequent use of CBD can lead to a longer duration in the system.
  • Individual Metabolism: Metabolic rates vary from person to person, influencing how quickly CBD is broken down and eliminated from the body.


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What the Research and Studies Say Regarding: How Long Does CBD Stay in Your System?

In the early 1990s, a study published in the Journal of Pharmacology and Biochemistry Behavior examined high doses of CBD and its concentration in the bloodstream. The study was performed over a six-week period, with participants taking 700 milligrams of CBD daily. After the six-week period of dosing ceased, the endocannabinoid levels in the blood remained “virtually undetectable” thereafter.

Thus, researchers suggested that the elimination of cannabidiol was estimated to be about 2 -5 days and this does not significantly differ between genders.

Published in Therapeutic Drug Monitoring, a 2005 randomized, double-blind, placebo-controlled study about the effects of cannabidiol after ingestion came to fruition. With 24 volunteers involved, each volunteer was either given 1) a soft-gelatin capsule with 10 mg of THC, 2) cannabis extract with 10 mg THC + 5.4 mg CBD, or 3) a placebo. Blood samples were taken at numerous time intervals after the intake. Researchers concluded that the cannabidiol was only detectable in the blood for up to 6 hours after oral administration.

The effect of CBD is small in comparison to variability caused by other factors, such as THC, in the bloodstream.

Yes, those research studies were solid in answering some questions about CBD in the bloodstream, but what about it being detectable in a urine sample? Hmmmm.

In 2016, a study was conducted in Chatsworth, CA in Pacific Toxicology Laboratories. Participants were given different types of cannabidiol-rich products. Just two hours after administration of these phytocannabinoid-rich products, 93% of participants tested positive for THC and CBD metabolites. For that one person that tested negative, the researchers found that their CBD was no longer detectable after 24 hours in their urine.

NanoCraft's Perspective on CBD Usage

At NanoCraft, we understand the importance of informed CBD usage. As an expert in the field, I recommend considering your specific needs and circumstances when using CBD. It's crucial to be aware of ‘how long does CBD stay in your system,’ especially if you're subject to drug testing, although CBD is generally not screened in standard drug tests.

Conclusion: Navigating CBD Use with Knowledge

In conclusion, while 'how long does CBD stay in your system' is a complex question, understanding the various factors that influence its duration can help you make informed decisions about your CBD use. With NanoCraft's commitment to providing high-quality CBD products, users can explore the benefits of CBD while being mindful of its presence in their system.


Consroe P, Kennedy K, Schram K. Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans. Pharmacol Biochem Behav. 1991. 
Nadulski T, Progst F, Weinberg G, et al. Randomized, double-lind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of tetrahydrocannabinol (THC) after oral application of THC versus standardized cannabis extract. Ther Drug Monit. 2005.

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Patrick Palmero is a man who embodies the spirit of wellness and adventure. As a certified nutritionist and accomplished writer for NanoCraft, Patrick brings a wealth of knowledge and experience to the world of health and fitness. His journey began as a professional surfer and snowboarder, where he honed not just his athletic skills but also developed a deep understanding of the importance of nutrition and well-being in peak performance.

Transitioning from the adrenaline-fueled world of professional sports, Patrick found his passion in helping others achieve their health and wellness goals. His expertise as a fitness enthusiast is not just theoretical but deeply rooted in his own experiences, making his advice and insights both practical and inspiring.

Beyond his professional pursuits, Patrick is a dedicated husband and father of two, living in sunny Southern California. His love for the outdoors continues to thrive, often spending his free time exploring nature's wonders with his family. Patrick's holistic approach to life - balancing career, family, and personal health - is a testament to his belief in living life to the fullest, and he brings this enthusiasm to the NanoCraft team and its community.