CBD x ANXIETY
In the past decade research on the effects of cannabis on both animal and human models have become of great interest to scientists and medical doctors professionals. Cannabidiol (CBD), a derivative of cannabis has been explained to have anxiolytic effects, meaning it has shown to significantly suppress anxiety and social anxiety interactions by acting on regions of the brain that control the responses to our environment.
ANIMALS x HUMANS
Cannabis research in the area of human applications and interactions in recent years have been extremely scarce, but animal models have been showing so much promise that research has been shifting the focus towards human interventions.
A research study conducted in 2011 was one of the first to examine both CBD impacts on anxiety and the underlying brain mechanism associated with the anxiolytic effects. Subjects with social anxiety disorders were given either 400mg/day of CBD in tincture form or a placebo. The effects of the CBD were measured by neuroimaging and by quantification of regional cerebral blood flow. Based on specialized statistical mapping the investigators were able to determine that CBD was in fact associated with a significant decrease in subjective measures of anxiety. These findings would suggest that CBD possesses anxiolytic application in the limbic and paralimbic regions of the brain, which are responsible for emotions, memories and arousal, Crippa et al., 2011.
The findings in the pervious study have also recently been supported by a study published in 2017, journal of psychopharmacology. The purpose of the study was to determine dose responses to CBD in individuals that underwent a public speaking intervention in a real life situation (TPSRS) and were assessed using the visual analogue mood scale (VAMS). There were a total of sixty subjects randomized in 5 groups that received either, a placebo, clonazepam (1mg) and CBD (100, 300, and 900mg/day) Zuardi et al., 2017.
The results indicated that acute administration of CBD produced anti-anxiety effects with a dose-dependent response in healthy subjects as seen in animal models. This was indicated by data analysis that explained subjective anxiety measures were reduced with CBD 300mg, but not with CBD 100mg and 900 mg, post intervention (TPSRS) Zuardi et al., 2017.
Studies are continuing to demonstrate the the safety and efficacy on cognition with CBD administration in both animal and human models without adverse effects. Now that the federal government has lifted legislation on industrial hemp It is believed that research will shift focus towards cannabis application to replace pharmaceutical drugs to treat ailments such as anxiety and social anxiety disorders. This would enable CBD to be utilized in a wide range of clinical applications, including anxiety and stress and has potential for a whole new avenue of natural treatment.
Although further research is needed to confirm recent findings, pre-clinical trials have demonstrated numerous times that cannabis pathways indeed play a role in multiple mechanism associated with anxiety and stress. Federal legislations have recently enabled the medical industry to take steps towards providing concrete research that will allow people to utilize safe and natural hemp remedies to improve disease and healthcare outcomes.
APPLICATIONS x CBD
New to CBD? check out the related link to the new user guide.
Cannabinoid options of application:
Transdermal (Skin)-Topical Salve: This application is typically used for acute and direct application. Such as an ankle sprain, arthritis, tendonitis, plantar fasciitis, carpal tunnel, tennis elbow, fibromyalgia and migraines. Full-spectrum salves provide a whole panel of cannabinoids for increased potency.
Tinctures: Tincture oils are utilized in full-spectrum form (whole plant derived) and Isolated forms (Pure CBD) that are applied directly under the tongue or mixed in water. This form is typically used for direct application to the central nervous system and the entire body for ailments like anxiety, stress, epilepsy, insomnia, depression, PTSD, autoimmune responses, ADHD, cancer, systemic inflammatory disease such as, cardiovascular disease, diabetes and metabolic syndrome. All applications are available as CBD isolate, broad spectrum and full spectrum.
Soft Gels: Full-spectrum soft gels essentially have the same application as tincture oils. The difference is that each soft gel is measured to a specific milligram to provide a consumer with a perfectly measured dose of CBD. This would be used for any ailments one might use CBD for, including all the ones listed above.
Superfood powder: Super food green powder has a broad range of greens, phytonutrients, vitamins and of course CBD. This application is great to give some a nice, clean energy boost before a workout or just to get your day started naturally with improved focus.
- Crippa JAS, Nogueira Derenusson G, Borduqui Ferrari T, et al. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: A preliminary report. J Psychopharmacol2011;
- Zuardi AW, Rodrigues NP, Silva AL, et al. Inverted U-shaped dose-response curve of the anxiolytic effect of cannabidiol during public speaking in real life. Front Pharmacol2017;
Athlete Relations x Physiologist
Kai Pattison was born and raised on the North Shore of Oahu, Hawaii. Kai graduated with a Master’s degree in clinical physiology from Point Loma Nazarene University. He is very passionate about human physiology and the applications in sport performance, recovery and clinical diagnostics. Kai has specialized in cardiopulmonary diagnostics, exercise induced energy expenditure and metabolism. Kai has also gained extensive research experience at UCSD on Parkinson’s disease. He enjoys educating and informing people on the importance of exercise to reduce risk of multiple inflammatory diseases, such as diabetes and heart disease. His passion for alternative medicine enables me to strive when promoting health and wellness.